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Titel:

Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Bailly-Maitre, B; Belgardt, BF; Jordan, SD; Coornaert, B; von Freyend, MJ; Kleinridders, A; Mauer, J; Cuddy, M; Kress, CL; Willmes, D; Essig, M; Hampel, B; Protzer, U; Reed, JC; Brüning, JC
Abstract:
The unfolded protein response (UPR) or endoplasmic reticulum (ER) stress response is a physiological process enabling cells to cope with altered protein synthesis demands. However, under conditions of obesity, prolonged activation of the UPR has been shown to have deteriorating effects on different metabolic pathways. Here we identify Bax inhibitor-1 (BI-1), an evolutionary conserved ER-membrane protein, as a novel modulator of the obesity-associated alteration of the UPR. BI-1 partially inhibit...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2010
Band / Volume:
285
Heft / Issue:
9
Seitenangaben Beitrag:
6198-207
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M109.056648
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19996103
Print-ISSN:
0021-9258
TUM Einrichtung:
Institut für Virologie
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