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Titel:

Magnetic and Acoustically Active Lipospheres for Magnetically Targeted Nucleic Acid Delivery

Dokumenttyp:
Article
Autor(en):
Vlaskou, D; Mykhaylyk, O; Krötz, F; Hellwig, N; Renner, R; Schillinger, U; Gleich, B; Heidsieck, A; Schmitz, G; Hensel, K; Plank, C
Abstract:
With the aim of obtaining a carrier for combined magnetic-field-and ultrasound-targeted nucleic acid delivery, acoustically active lipospheres are prepared that comprise magnetic nanoparticles and plasmid DNA or synthetic siRNA. The lipospheres, with average diameters of 5 mu m and smaller, are obtained upon shaking a mixture of soybean oil, a cationic lipid, magnetic nanoparticles, a nucleic acid, and aqueous buffer in a perfluoropropane atmosphere in a sealed vial. These lipospheres create con...     »
Zeitschriftentitel:
Adv. Funct. Mater.
Jahr:
2010
Band / Volume:
20
Heft / Issue:
22
Seitenangaben Beitrag:
3881-3894
Sprache:
eng
Print-ISSN:
1616-301X
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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