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Title:

Antigen delivery to plasmacytoid dendritic cells via BST2 induces protective T cell-mediated immunity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Loschko, J; Schlitzer, A; Dudziak, D; Drexler, I; Sandholzer, N; Bourquin, C; Reindl, W; Krug, AB
Abstract:
Plasmacytoid dendritic cells (PDCs) are capable of presenting Ags to T cells in a tolerogenic or immunogenic manner depending on the formulation of the Ag and the mode of stimulation. It has not been investigated whether effective adaptive immune responses useful for vaccination can be induced by Ab-mediated Ag targeting to PDCs in vivo. In this study, we show that Ag delivered to murine PDCs via bone marrow stromal cell Ag 2 (BST2)/CD317 in combination with TLR agonists as adjuvants is specific...     »
Journal title abbreviation:
J Immunol
Year:
2011
Journal volume:
186
Journal issue:
12
Pages contribution:
6718-25
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.1004029
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21555533
Print-ISSN:
0022-1767
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Virologie
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