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Titel:

Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-?-dependent induction of pro-apoptotic Noxa.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Eitz Ferrer, P; Potthoff, S; Kirschnek, S; Gasteiger, G; Kastenmuller, W; Ludwig, H; Paschen, SA; Villunger, A; Sutter, G; Drexler, I; Häcker, G
Abstract:
Viral infection is a stimulus for apoptosis, and in order to sustain viral replication many viruses are known to carry genes encoding apoptosis inhibitors. F1L, encoded by the orthopoxvirus modified vaccinia virus Ankara (MVA) has a Bcl-2-like structure. An MVA mutant lacking F1L (MVA?F1L) induces apoptosis, indicating that MVA infection activates and F1L functions to inhibit the apoptotic pathway. In this study we investigated the events leading to apoptosis upon infection by MVA?F1L. Apoptosis...     »
Zeitschriftentitel:
PLoS Pathog
Jahr:
2011
Band / Volume:
7
Heft / Issue:
6
Seitenangaben Beitrag:
e1002083
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.ppat.1002083
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21698224
Print-ISSN:
1553-7366
TUM Einrichtung:
Institut für Virologie
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