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Title:

KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification.

Document type:
Journal Article
Author(s):
Bürck, Carolin; Mund, Andreas; Berscheminski, Julia; Kieweg, Lisa; Müncheberg, Sarah; Dobner, Thomas; Schreiner, Sabrina
Abstract:
Once transported to the replication sites, human adenoviruses (HAdVs) need to ensure decondensation and transcriptional activation of their viral genomes to synthesize viral proteins and initiate steps to reprogram the host cell for viral replication. These early stages during adenoviral infection are poorly characterized but represent a decisive moment in the establishment of a productive infection. Here, we identify a novel host viral restriction factor, KAP1. This heterochromatin-associated t...     »
Journal title abbreviation:
J Virol
Year:
2015
Journal volume:
90
Journal issue:
2
Pages contribution:
930-46
Language:
eng
Fulltext / DOI:
doi:10.1128/JVI.01836-15
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26537675
Print-ISSN:
0022-538X
TUM Institution:
Institut für Virologie
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