Login
- Dokumenttyp:
- journal article
- Autor(en):
- Serebrakian, Arman T, AT; Poulos, Theresa, T; Liebl, Hans, H; Joseph, Gabby B, GB; Lai, Andrew, A; Nevitt, Michael C, MC; Lynch, John A, JA; McCulloch, Charles E, CE; Link, Thomas M, TM
- Titel:
- Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative.
- Abstract:
- To assess whether changes in knee cartilage MR-based T2 relaxation times are associated with weight loss in individuals with risk factors for knee osteoarthritis (OA) compared with controls with stable weight.One hundred twenty-seven individuals with risk factors for knee OA were studied: 62 subjects had a body mass index (BMI) decrease>=10% over 48 months and 65 controls had a BMI change<3%. Cartilage segmentation from five knee compartments at baseline and 48-month follow-up was performed, and T2 maps were generated. The association of change in T2 values over 48 months in the weight-loss group versus the control group was assessed using multiple linear regression models.Weight loss was associated with significantly smaller increases in cartilage T2 in the medial femoral condyle (P = 0.035) and overall medial compartment (P = 0.006) compared with the controls. In a subgroup analysis comparing weight-loss subjects who were obese (BMI>=30 kg/m(2) ) and overweight (BMI 25-30 kg/m(2) ) at baseline, obesity was associated with smaller increases in cartilage T2 values in the medial femoral condyle (P = 0.022), lateral femoral condyle (P = 0.015), patella (P = 0.002), and globally across all compartments (P = 0.002).A decrease in BMI of>= 10% was associated with a slower progression of T2 values in individuals with risk factors for OA, suggesting a beneficial impact of weight loss on cartilage matrix degeneration.
- Zeitschriftentitel:
- J Magn Reson Imaging
- Jahr:
- 2015
- Band / Volume:
- 41
- Heft / Issue:
- 5
- Seitenangaben Beitrag:
- 1272-80
- Sprache:
- eng
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/24700497
- Print-ISSN:
- 1053-1807
- TUM Einrichtung:
- Institut für Radiologie
BibTeX