Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative.

Serebrakian, Arman T, AT; Poulos, Theresa, T; Liebl, Hans, H; Joseph, Gabby B, GB; Lai, Andrew, A; Nevitt, Michael C, MC; Lynch, John A, JA; McCulloch, Charles E, CE; Link, Thomas M, TM

journal article

Titel:: Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative.
Dokumenttyp:: journal article
Autor(en):: Serebrakian, Arman T, AT; Poulos, Theresa, T; Liebl, Hans, H; Joseph, Gabby B, GB; Lai, Andrew, A; Nevitt, Michael C, MC; Lynch, John A, JA; McCulloch, Charles E, CE; Link, Thomas M, TM
Abstract:: To assess whether changes in knee cartilage MR-based T2 relaxation times are associated with weight loss in individuals with risk factors for knee osteoarthritis (OA) compared with controls with stable weight.One hundred twenty-seven individuals with risk factors for knee OA were studied: 62 subjects had a body mass index (BMI) decrease>=10% over 48 months and 65 controls had a BMI change<3%. Cartilage segmentation from five knee compartments at baseline and 48-month follow-up was performed, and T2 maps were generated. The association of change in T2 values over 48 months in the weight-loss group versus the control group was assessed using multiple linear regression models.Weight loss was associated with significantly smaller increases in cartilage T2 in the medial femoral condyle (P = 0.035) and overall medial compartment (P = 0.006) compared with the controls. In a subgroup analysis comparing weight-loss subjects who were obese (BMI>=30 kg/m(2) ) and overweight (BMI 25-30 kg/m(2) ) at baseline, obesity was associated with smaller increases in cartilage T2 values in the medial femoral condyle (P = 0.022), lateral femoral condyle (P = 0.015), patella (P = 0.002), and globally across all compartments (P = 0.002).A decrease in BMI of>= 10% was associated with a slower progression of T2 values in individuals with risk factors for OA, suggesting a beneficial impact of weight loss on cartilage matrix degeneration.
Zeitschriftentitel:: J Magn Reson Imaging
Jahr:: 2015
Band / Volume:: 41
Heft / Issue:: 5
Seitenangaben Beitrag:: 1272-80
Sprache:: eng
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/24700497
Print-ISSN:: 1053-1807
TUM Einrichtung:: Institut für Radiologie
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