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Titel:

Mast cell-nerve axis with a focus on the human gut.

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Buhner, Sabine; Schemann, Michael
Abstract:
This paper summarizes the current knowledge on the interactions between intestinal mast cells, enteric neurons and visceral afferents which are part of the gut brain axis. The focus of this review is on the relevance of the mast cell-nerve axis in the human intestine. Similarities and important differences in the organization of the mast cell-nerve axis between human and rodents are discussed. Functionally important human mast cell mediators with neural actions in the human ENS are histamine (H1...     »
Stichworte:
Signal Transduction, Animals, Humans, Cell Communication, Enteric Nervous System/immunology/pathology, Inflammation/immunology/metabolism, Inflammation Mediators/metabolism, Neuroimmunomodulation, Gastrointestinal Tract/immunology/innervation/*pathology, Mast Cells/immunology/*metabolism/pathology, Neurons, Afferent/immunology/*metabolism/pathology
Zeitschriftentitel:
Biochimica et biophysica acta
Jahr:
2012
Band / Volume:
1822
Monat:
jan
Heft / Issue:
1
Seitenangaben Beitrag:
85--92
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.bbadis.2011.06.004
Print-ISSN:
0006-3002 0006-3002
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