Benutzer: Gast  Login
Titel:

The mast cell degranulator compound 48/80 directly activates neurons.

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Schemann, Michael; Kugler, Eva Maria; Buhner, Sabine; Eastwood, Christopher; Donovan, Jemma; Jiang, Wen; Grundy, David
Abstract:
BACKGROUND: Compound 48/80 is widely used in animal and tissue models as a "selective" mast cell activator. With this study we demonstrate that compound 48/80 also directly activates enteric neurons and visceral afferents. METHODOLOGY/PRINCIPAL FINDINGS: We used in vivo recordings from extrinsic intestinal afferents together with Ca(++) imaging from primary cultures of DRG and nodose neurons. Enteric neuronal activation was examined by Ca(++) and voltage sensitive dye imaging in isolated gut pre...     »
Stichworte:
Animals, Guinea Pigs, Male, Neurons/*drug effects/metabolism, Calcium Signaling/drug effects, Enteric Nervous System/drug effects, Ganglia, Spinal/drug effects/metabolism, Nodose Ganglion/drug effects/metabolism, p-Methoxy-N-methylphenethylamine/administration & dosage/*pharmacology, Sensory Receptor Cells/drug effects/metabolism, Visceral Afferents/drug effects
Zeitschriftentitel:
PloS one
Jahr:
2012
Band / Volume:
7
Heft / Issue:
12
Seitenangaben Beitrag:
e52104
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0052104
Print-ISSN:
1932-6203 1932-6203
 BibTeX