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Titel:

Diet-induced obesity has neuroprotective effects in murine gastric enteric nervous system: involvement of leptin and glial cell line-derived neurotrophic factor.

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Baudry, Charlotte; Reichardt, Francois; Marchix, Justine; Bado, Andre; Schemann, Michael; des Varannes, Stanislas Bruley; Neunlist, Michel; Moriez, Raphael
Abstract:
Nutritional factors can induce profound neuroplastic changes in the enteric nervous system (ENS), responsible for changes in gastrointestinal (GI) motility. However, long-term effects of a nutritional imbalance leading to obesity, such as Western diet (WD), upon ENS phenotype and control of GI motility remain unknown. Therefore, we investigated the effects of WD-induced obesity (DIO) on ENS phenotype and function as well as factors involved in functional plasticity. Mice were fed with normal d...     »
Stichworte:
Mice, Inbred C57BL, Cells, Cultured, Gastric Emptying, Animals, Mice, Male, Rats, Myenteric Plexus/*physiology, *Diet, *Neuroprotective Agents/pharmacology, Acetylcholine/physiology, Glial Cell Line-Derived Neurotrophic Factor/*physiology, Jejunum/innervation/physiology, Leptin/pharmacology/*physiology, Obesity/*physiopathology, Pyloric Antrum/innervation/physiology, RNA, Messenger/metabolism
Zeitschriftentitel:
The Journal of physiology
Jahr:
2012
Band / Volume:
590
Monat:
feb
Heft / Issue:
3
Seitenangaben Beitrag:
533--544
Sprache:
eng
Volltext / DOI:
doi:10.1113/jphysiol.2011.219717
Print-ISSN:
1469-7793 0022-3751
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