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Titel:

Extrinsic intestinal denervation modulates tumor development in the small intestine of {Apc}({Min}/+) mice.

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Liu, Verena; Dietrich, Alexandra; Kasparek, Michael S.; Benhaqi, Petra; Schneider, Marlon R.; Schemann, Michael; Seeliger, Hendrik; Kreis, Martin E.
Abstract:
BACKGROUND: Innervation interacts with enteric immune responses. Chronic intestinal inflammation is associated with increased risk of colorectal cancer. We aimed to study potential extrinsic neuronal modulation of intestinal tumor development in a mouse model. METHODS: Experiments were performed with male Apc(Min/+) or wild type mice (4 weeks old, body weight approximately 20 g). Subgroups with subdiaphragmatic vagotomy (apcV/wtV), sympathetic denervation of the small intestine (apcS/wtS) or sha...     »
Stichworte:
Mice, Knockout, Disease Models, Animal, Animals, Mice, Male, *Cell Transformation, Neoplastic, *Denervation, Adenomatous Polyposis Coli Protein/deficiency, Colorectal Neoplasms/*etiology/*pathology, Ileum/pathology, Intestine, Small/*innervation, Tumor Burden
Zeitschriftentitel:
Journal of experimental & clinical cancer research : CR
Jahr:
2015
Band / Volume:
34
Monat:
apr
Seitenangaben Beitrag:
39
Sprache:
eng
Volltext / DOI:
doi:10.1186/s13046-015-0159-0
Print-ISSN:
1756-9966 0392-9078
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