Reduced {Responses} of {Submucous} {Neurons} from {Irritable} {Bowel} {Syndrome} {Patients} to  a {Cocktail} {Containing} {Histamine}, {Serotonin}, {TNFalpha}, and {Tryptase} ({IBS}-{Cocktail}).

Document type:: Zeitschriftenaufsatz
Author(s):: Ostertag, Daniela; Buhner, Sabine; Michel, Klaus; Pehl, Christian; Kurjak, Manfred; Gotzberger, Manuela; Schulte-Frohlinde, Ewert; Frieling, Thomas; Enck, Paul; Phillip, Josef; Schemann, Michael
Title:: Reduced {Responses} of {Submucous} {Neurons} from {Irritable} {Bowel} {Syndrome} {Patients} to a {Cocktail} {Containing} {Histamine}, {Serotonin}, {TNFalpha}, and {Tryptase} ({IBS}-{Cocktail}).
Abstract:: BACKGROUND AND AIMS: Malfunctions of enteric neurons are believed to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Our aim was to investigate whether neuronal activity in biopsies from IBS patients is altered in comparison to healthy controls (HC). METHODS: Activity of human submucous neurons in response to electrical nerve stimulation and local application of nicotine or a mixture of histamine, serotonin, tryptase, and
Keywords:: irritable bowel syndrome, calcium imaging, colonic biopsy, enteric nerve desensitization, immune mediators, submucous plexus
Journal title:: Frontiers in neuroscience
Year:: 2015
Journal volume:: 9
Pages contribution:: 465
Language:: eng
Fulltext / DOI:: doi:10.3389/fnins.2015.00465
Print-ISSN:: 1662-4548 1662-453X
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