Reduced {Responses} of {Submucous} {Neurons} from {Irritable} {Bowel} {Syndrome} {Patients} to  a {Cocktail} {Containing} {Histamine}, {Serotonin}, {TNFalpha}, and {Tryptase} ({IBS}-{Cocktail}).

Dokumenttyp:: Zeitschriftenaufsatz
Autor(en):: Ostertag, Daniela; Buhner, Sabine; Michel, Klaus; Pehl, Christian; Kurjak, Manfred; Gotzberger, Manuela; Schulte-Frohlinde, Ewert; Frieling, Thomas; Enck, Paul; Phillip, Josef; Schemann, Michael
Titel:: Reduced {Responses} of {Submucous} {Neurons} from {Irritable} {Bowel} {Syndrome} {Patients} to a {Cocktail} {Containing} {Histamine}, {Serotonin}, {TNFalpha}, and {Tryptase} ({IBS}-{Cocktail}).
Abstract:: BACKGROUND AND AIMS: Malfunctions of enteric neurons are believed to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Our aim was to investigate whether neuronal activity in biopsies from IBS patients is altered in comparison to healthy controls (HC). METHODS: Activity of human submucous neurons in response to electrical nerve stimulation and local application of nicotine or a mixture of histamine, serotonin, tryptase, and
Stichworte:: irritable bowel syndrome, calcium imaging, colonic biopsy, enteric nerve desensitization, immune mediators, submucous plexus
Zeitschriftentitel:: Frontiers in neuroscience
Jahr:: 2015
Band / Volume:: 9
Seitenangaben Beitrag:: 465
Sprache:: eng
Volltext / DOI:: doi:10.3389/fnins.2015.00465
Print-ISSN:: 1662-4548 1662-453X
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