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- Title:
Neuropharmacology of purinergic receptors in human submucous plexus: {Involvement} of {P}2X(1), {P}2X(2), {P}2X(3) channels, {P}2Y and {A}(3) metabotropic receptors in neurotransmission.
- Document type:
- Zeitschriftenaufsatz
- Author(s):
- Linan-Rico, A.; Wunderlich, J. E.; Enneking, J. T.; Tso, D. R.; Grants, I.; Williams, K. C.; Otey, A.; Michel, K.; Schemann, M.; Needleman, B.; Harzman, A.; Christofi, F. L.
- Abstract:
- RATIONALE: The role of purinergic signaling in human ENS is not well understood. We sought to further characterize the neuropharmacology of purinergic receptors in human ENS and test the hypothesis that endogenous purines are critical regulators of neurotransmission. EXPERIMENTAL APPROACH:
- Keywords:
- ATP, Voltage-Sensitive Dye Imaging, Immunohistochemistry, Colectomy, A(3) inhibitory receptors, Endogenous adenosine, Human enteric nervous system, Inhibitory P2Y receptors, P2X channels, Purinergic synaptic transmission, Electric Stimulation, Calcium/metabolism, Humans, Excitatory Postsynaptic Potentials/physiology, Adenosine Triphosphate/metabolism, Neurons/*drug effects/*physiology, Purinergic Agents/pharmacology, Receptors, Purinergic/*metabolism, Submucous plexus, Submucous Plexus/*drug eff... »
- Journal title:
- Neuropharmacology
- Year:
- 2015
- Journal volume:
- 95
- Month:
- aug
- Pages contribution:
- 83--99
- Language:
- eng
- Fulltext / DOI:
- doi:10.1016/j.neuropharm.2015.02.014
- Print-ISSN:
- 1873-7064 0028-3908
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