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Heydenreuter, Wolfgang;Kunold, Elena;Sieber, Stephan A.
Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site
Chem. Commun.
2015
51
87
15784-15787
Gersch, Malte;Famulla, Kirsten;Dahmen, Maria;Göbl, Christoph;Malik, Imran;Richter, Klaus;Korotkov, Vadim S.;Sass, Peter;Rübsamen-Schaeff, Helga;Madl, Tobias;Brötz-Oesterhelt, Heike;Sieber, Stephan A.
AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control
Nature Communications
2015
6320
Hackl, Mathias W.;Lakemeyer, Markus;Dahmen, Maria;Glaser, Manuel;Pahl, Axel;Lorenz-Baath, Katrin;Menzel, Thomas;Sievers, Sonja;Böttcher, Thomas;Antes, Iris;Waldmann, Herbert;Sieber, Stephan A.
Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization
J. Am. Chem. Soc.
2015
137
26
8475-8483
Artola, Marta;Ruiz-Avila, Laura B.;Vergoñós, Albert;Huecas, Sonia;Araujo-Bazán, Lidia;Martín-Fontecha, Mar;Vázquez-Villa, Henar;Turrado, Carlos;Ramírez-Aportela, Erney;Hoegl, Annabelle;Nodwell, Matthew;Barasoain, Isabel;Chacón, Pablo;Sieber, Stephan A.;Andreu, Jose M.;López-Rodríguez, María L.
Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action
ACS Chem. Biol.
2015
10
834-843
Gersch, Malte;Hackl, Mathias W.;Dubiella, Christian;Dobrinevski, Alexander;Groll, Michael;Sieber, Stephan A.
A Mass Spectrometry Platform for a Streamlined Investigation of Proteasome Integrity, Posttranslational Modifications, and Inhibitor Binding
Chemistry & Biology
2015
22
404-411
Wiedemann, Elija N.;Mandl, Franziska A.;Blank, Iris D.;Ochsenfeld, Christian;Ofial, Armin R.;Sieber, Stephan A.
Kinetic and Theoretical Studies of Beta-Lactone Reactivity-A Quantitative Scale for Biological Application
ChemPlusChem
2015
80
11
1673-1679
Zhao, Weining;Lorenz, Nicola;Jung, Kirsten;Sieber, Stephan A.
Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity
Angewandte Chemie International Edition
2015
55
1187-1191
Pahl, Axel;Lakemeyer, Markus;Vielberg, Marie-Theres;Hackl, Mathias W.;Vomacka, Jan;Korotkov, Vadim S.;Stein, Martin L.;Fetzer, Christian;Lorenz-Baath, Katrin;Richter, Klaus;Waldmann, Herbert;Groll, Michael;Sieber, Stephan A.
Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association
Angewandte Chemie International Edition
2015
54
52
15892-15896
Dahmen, Maria;Vielberg, Marie-Theres;Groll, Michael;Sieber, Stephan A.
Structure and Mechanism of the Caseinolytic Protease ClpP1/2 Heterocomplex from Listeria monocytogenes
Angewandte Chemie International Edition
2015
54
12
3598-3602
Koch, Maximilian F.;Harteis, Sabrina;Blank, Iris D.;Pestel, Galina;Tietze, Lutz F.;Ochsenfeld, Christian;Schneider, Sabine;Sieber, Stephan A.
Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues
Angewandte Chemie
2015
127
46
13754-13758
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