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Titel:

Bioactivation of dermal scaffolds with a non-viral copolymer-protected gene vector.

Dokumenttyp:
Journal Article; Article
Autor(en):
Reckhenrich, AK; Hopfner, U; Krötz, F; Zhang, Z; Koch, C; Kremer, M; Machens, HG; Plank, C; Egana, JT
Abstract:
The use of scaffolds in skin tissue engineering is accompanied with low regeneration rates and high risk of infection. In this study, we activated an FDA-approved collagen scaffold for dermal regeneration by incorporation of copolymer-protected gene vectors (COPROGs) to induce a temporary release of VEGF. In vitro results show that the presence of COPROGs did not affect the distribution, attachment, proliferation and viability of cells in the scaffold. A transient release of VEGF was observed fo...     »
Zeitschriftentitel:
Biomaterials
Jahr:
2011
Band / Volume:
32
Heft / Issue:
7
Seitenangaben Beitrag:
1996-2003
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.biomaterials.2010.11.022
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21159378
Print-ISSN:
0142-9612
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung; Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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