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Title:

Ovulation is triggered by a cyclical modulation of gonadotropes into a hyperexcitable state.

Document type:
Journal Article
Author(s):
Götz, Viktoria; Qiao, Sen; Das, Debajyoti; Wartenberg, Philipp; Wyatt, Amanda; Wahl, Vanessa; Gamayun, Igor; Alasmi, Samer; Fecher-Trost, Claudia; Meyer, Markus R; Rad, Roland; Kaltenbacher, Thorsten; Kattler, Kathrin; Lipp, Peter; Becherer, Ute; Mollard, Patrice; Candlish, Michael; Boehm, Ulrich
Abstract:
Gonadotropes in the anterior pituitary gland are essential for fertility and provide a functional link between the brain and the gonads. To trigger ovulation, gonadotrope cells release massive amounts of luteinizing hormone (LH). The mechanism underlying this remains unclear. Here, we utilize a mouse model expressing a genetically encoded Ca2+ indicator exclusively in gonadotropes to dissect this mechanism in intact pituitaries. We demonstrate that female gonadotropes exclusively exhibit a state...     »
Journal title abbreviation:
Cell Rep
Year:
2023
Journal volume:
42
Journal issue:
6
Fulltext / DOI:
doi:10.1016/j.celrep.2023.112543
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37224016
Print-ISSN:
2211-1247
TUM Institution:
Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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