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Titel:

Immune‐Informed Mucin Hydrogels Evade Fibrotic Foreign Body Response In Vivo

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Yan, Hongji; Seignez, Cédric; Hjorth, Morgan; Winkeljann, Benjamin; Blakeley, Matthew; Lieleg, Oliver; Phillipson, Mia; Crouzier, Thomas
Abstract:
The immune‐mediated foreign body response to biomaterial implants can trigger the formation of insulating fibrotic capsules that can compromise implant function. To address this challenge, the intrinsic bioactivity of the mucin biopolymer, a heavily glycosylated protein that forms the protective mucus gel covering mucosal epithelia, is leveraged. By using a bioorthogonal inverse electron demand Diels–Alder reaction, mucins are crosslinked into implantable hydrogels. It is shown that mucin hydrog...     »
Stichworte:
B cells bovine submaxillary mucin fibrosis foreign body response hydrogels macrophages TGF‐β1
Zeitschriftentitel:
Advanced Functional Materials
Jahr:
2019
Jahr / Monat:
2019-09
Seitenangaben Beitrag:
1902581
Nachgewiesen in:
Web of Science
Sprache:
en
Volltext / DOI:
doi:10.1002/adfm.201902581
WWW:
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201902581
Verlag / Institution:
Wiley
E-ISSN:
1616-301X1616-3028
Publikationsdatum:
12.09.2019
TUM Einrichtung:
Fachgebiet für Biomechanik
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