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Title:

Immune‐Informed Mucin Hydrogels Evade Fibrotic Foreign Body Response In Vivo

Document type:
Zeitschriftenaufsatz
Author(s):
Yan, Hongji; Seignez, Cédric; Hjorth, Morgan; Winkeljann, Benjamin; Blakeley, Matthew; Lieleg, Oliver; Phillipson, Mia; Crouzier, Thomas
Abstract:
The immune‐mediated foreign body response to biomaterial implants can trigger the formation of insulating fibrotic capsules that can compromise implant function. To address this challenge, the intrinsic bioactivity of the mucin biopolymer, a heavily glycosylated protein that forms the protective mucus gel covering mucosal epithelia, is leveraged. By using a bioorthogonal inverse electron demand Diels–Alder reaction, mucins are crosslinked into implantable hydrogels. It is shown that mucin hydrog...     »
Keywords:
B cells bovine submaxillary mucin fibrosis foreign body response hydrogels macrophages TGF‐β1
Journal title:
Advanced Functional Materials
Year:
2019
Year / month:
2019-09
Pages contribution:
1902581
Covered by:
Web of Science
Language:
en
Fulltext / DOI:
doi:10.1002/adfm.201902581
WWW:
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201902581
Publisher:
Wiley
E-ISSN:
1616-301X1616-3028
Date of publication:
12.09.2019
TUM Institution:
Fachgebiet für Biomechanik
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