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Title:

α-Synuclein Penetrates Mucin Hydrogels Despite Its Mucoadhesive Properties

Document type:
Zeitschriftenaufsatz
Author(s):
Marczynski, Matthias; Rickert, Carolin A.; Semerdzhiev, Slav A.; van Dijk, Wouter R.; Segers-Nolten, Ine M. J.; Claessens, Mireille M. A. E.; Lieleg, Oliver
Abstract:
Recent research indicates that the progression of Parkinson’s disease can start from neurons of the enteric nervous system, which are in close contact with the gastrointestinal epithelium: α-synuclein molecules can be transferred from these epithelial cells in a prion-like fashion to enteric neurons. Thin mucus layers constitute a defense line against the exposure of noninfected cells to potentially harmful α-synuclein species. We show that—despite its mucoadhesive properties—α-synuclein can tra...     »
Keywords:
Peptides and proteins, Monomers, Fluorescenc Molecules, Hydrogels
Dewey Decimal Classification:
500 Naturwissenschaften
Journal title:
Biomacromolecules
Year:
2019
Journal volume:
20
Journal issue:
12
Pages contribution:
4332-4344
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1021/acs.biomac.9b00905
WWW:
https://pubs.acs.org/doi/10.1021/acs.biomac.9b00905
Publisher:
American Chemical Society (ACS)
E-ISSN:
1525-77971526-4602
Date of publication:
13.11.2019
Semester:
WS 19-20
TUM Institution:
Fachgebiet für Biomechanik, MW
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