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Titel:

Glyco-Modification of Mucin Hydrogels to Investigate Their Immune Activity

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Yan, Hongji; Hjorth, Morgan; Winkeljann, Benjamin; Dobryden, Illia; Lieleg, Oliver; Crouzier, Thomas
Abstract:
Mucins are multifunctional glycosylated proteins that are increasingly investigated as building blocks of novel biomaterials. An attractive feature is their ability to modulate the immune response, in part by engaging with sialic acid binding receptors on immune cells. Once assembled into hydrogels, bovine submaxillary mucins (Muc gels) were shown to modulate the recruitment and activation of immune cells and avoid fibrous encapsulation in vivo. However, nothing is known about the early immune r...     »
Stichworte:
glyco-modulation, macrophages, mucin hydrogels, sialic acid, surface nanomechanical property
Dewey Dezimalklassifikation:
500 Naturwissenschaften
Zeitschriftentitel:
ACS Applied Materials & Interfaces
Jahr:
2020
Band / Volume:
12
Heft / Issue:
17
Seitenangaben Beitrag:
19324-19336
Nachgewiesen in:
Scopus
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1021/acsami.0c03645
WWW:
https://pubs.acs.org/doi/10.1021/acsami.0c03645
Verlag / Institution:
American Chemical Society (ACS)
E-ISSN:
1944-82441944-8252
Publikationsdatum:
17.04.2020
TUM Einrichtung:
Fachgebiet für Biomechanik
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