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Titel:

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wing, Peter Ac; Davenne, Tamara; Wettengel, Jochen; Lai, Alvina G; Zhuang, Xiaodong; Chakraborty, Anindita; D'Arienzo, Valentina; Kramer, Catharina; Ko, Chunkyu; Harris, James M; Schreiner, Sabrina; Higgs, Martin; Roessler, Stephanie; Parish, Joanna L; Protzer, Ulrike; Balfe, Peter; Rehwinkel, Jan; McKeating, Jane A
Abstract:
Chronic hepatitis B is one of the world's unconquered diseases with more than 240 million infected subjects at risk of developing liver disease and hepatocellular carcinoma. Hepatitis B virus reverse transcribes pre-genomic RNA to relaxed circular DNA (rcDNA) that comprises the infectious particle. To establish infection of a naïve target cell, the newly imported rcDNA is repaired by host enzymes to generate covalently closed circular DNA (cccDNA), which forms the transcriptional template for vi...     »
Zeitschriftentitel:
Life Sci Alliance
Jahr:
2019
Band / Volume:
2
Heft / Issue:
2
Volltext / DOI:
doi:10.26508/lsa.201900355
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30918010
TUM Einrichtung:
Institut für Virologie
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