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Titel:

PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice.

Dokumenttyp:
Journal Article
Autor(en):
Xia, Yuchen; Schlapschy, Martin; Morath, Volker; Roeder, Natalie; Vogt, Elisabeth I; Stadler, Daniela; Cheng, Xiaoming; Dittmer, Ulf; Sutter, Kathrin; Heikenwälder, Mathias; Skerra, Arne; Protzer, Ulrike
Abstract:
Interferon α (IFNα) so far is the only therapeutic option for chronic hepatitis B virus (HBV) infection that can lead to virus clearance. Unfortunately, its application is limited by side effects and response rates are low. The aim of this study was to generate a novel long-acting IFNα with the help of PASylation technology that adds a polypeptide comprising Proline, Alanine and Serine (PAS) to increase plasma half-life. Following evaluation of four selected recombinant murine IFNα (mIFNα) subty...     »
Zeitschriftentitel:
Antiviral Res
Jahr:
2019
Band / Volume:
161
Seitenangaben Beitrag:
134-143
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.antiviral.2018.11.003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30439382
Print-ISSN:
0166-3542
TUM Einrichtung:
Institut für Virologie ; Klinik und Poliklinik für Nuklearmedizin
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