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Titel:

A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection.

Dokumenttyp:
Journal Article
Autor(en):
Ko, Chunkyu; Bester, Romina; Zhou, Xue; Xu, Zhiheng; Blossey, Christoph; Sacherl, Julia; Vondran, Florian W R; Gao, Lu; Protzer, Ulrike
Abstract:
Hepatitis B virus (HBV) is a major human pathogen, killing an estimated 887,000 people per year. Therefore, potentially curative therapies are of high importance. Following infection, HBV deposits a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that serves as a transcription template and is not affected by current therapies. HBV core protein allosteric modulators (CpAMs) prevent correct capsid assembly but may also affect early stages of HBV infection. In this study, w...     »
Zeitschriftentitel:
Antimicrob Agents Chemother
Jahr:
2019
Band / Volume:
64
Heft / Issue:
1
Volltext / DOI:
doi:10.1128/AAC.01440-19
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31658963
Print-ISSN:
0066-4804
TUM Einrichtung:
Institut für Virologie
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