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Titel:

Revisiting Hepatitis B Virus: Challenges of Curative Therapies.

Dokumenttyp:
Journal Article; Review
Autor(en):
Hu, Jianming; Protzer, Ulrike; Siddiqui, Aleem
Abstract:
With a yearly death toll of 880,000, hepatitis B virus (HBV) remains a major health problem worldwide, despite an effective prophylactic vaccine and well-tolerated, effective antivirals. HBV causes chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The viral genome persists in infected hepatocytes even after long-term antiviral therapy, and its integration, though no longer able to support viral replication, destabilizes the host genome. HBV is a DNA virus that utilizes a viru...     »
Zeitschriftentitel:
J Virol
Jahr:
2019
Band / Volume:
93
Heft / Issue:
20
Volltext / DOI:
doi:10.1128/JVI.01032-19
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31375584
Print-ISSN:
0022-538X
TUM Einrichtung:
Institut für Virologie
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