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Titel:

T cell receptor grafting allows virological control of Hepatitis B virus infection.

Dokumenttyp:
Journal Article
Autor(en):
Wisskirchen, Karin; Kah, Janine; Malo, Antje; Asen, Theresa; Volz, Tassilo; Allweiss, Lena; Wettengel, Jochen M; Lütgehetmann, Marc; Urban, Stephan; Bauer, Tanja; Dandri, Maura; Protzer, Ulrike
Abstract:
T cell therapy is a promising means to treat chronic HBV infection and HBV-associated hepatocellular carcinoma. T cells engineered to express an HBV-specific T cell receptor (TCR) may achieve cure of HBV infection upon adoptive transfer. We investigated the therapeutic potential and safety of T cells stably expressing high affinity HBV envelope- or core-specific TCRs recognizing European and Asian HLA-A2 subtypes. Both CD8+ and CD4+ T cells from healthy donors and from chronic hepatitis B patien...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2019
Band / Volume:
129
Heft / Issue:
7
Seitenangaben Beitrag:
2932-2945
Volltext / DOI:
doi:10.1172/JCI120228
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31039136
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Virologie
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