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Title:

Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints.

Document type:
Journal Article
Author(s):
Kappler, Lisa; Hoene, Miriam; Hu, Chunxiu; von Toerne, Christine; Li, Jia; Bleher, Daniel; Hoffmann, Christoph; Böhm, Anja; Kollipara, Laxmikanth; Zischka, Hans; Königsrainer, Alfred; Häring, Hans-Ulrich; Peter, Andreas; Xu, Guowang; Sickmann, Albert; Hauck, Stefanie M; Weigert, Cora; Lehmann, Rainer
Abstract:
Mitochondria are dynamic organelles with diverse functions in tissues such as liver and skeletal muscle. To unravel the mitochondrial contribution to tissue-specific physiology, we performed a systematic comparison of the mitochondrial proteome and lipidome of mice and assessed the consequences hereof for respiration. Liver and skeletal muscle mitochondrial protein composition was studied by data-independent ultra-high-performance (UHP)LC-MS/MS-proteomics, and lipid profiles were compared by UHP...     »
Journal title abbreviation:
Am J Physiol Endocrinol Metab
Year:
2019
Journal volume:
317
Journal issue:
2
Pages contribution:
E374-E387
Fulltext / DOI:
doi:10.1152/ajpendo.00088.2019
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31211616
Print-ISSN:
0193-1849
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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