Colon Cancer: Epithelial Notch Signaling Recruits Neutrophils to Drive Metastasis.

Title:: Colon Cancer: Epithelial Notch Signaling Recruits Neutrophils to Drive Metastasis.
Document type:: Journal Article; Research Support, Non-U.S. Gov't; Comment
Author(s):: Ruland, Jürgen
Abstract:: In this issue of Cancer Cell, Jackstadt et al. report that pathological Notch signaling in colorectal cancer (CRC) cells can initiate a neutrophil-dependent, TGF-β-mediated cascade that leads to metastatic disease. Inhibition of this pathway with clinically relevant compounds blocks metastatic spread in a developed murine model of CRC.
Journal title abbreviation:: Cancer Cell
Year:: 2019
Journal volume:: 36
Journal issue:: 3
Pages contribution:: 213-214
Fulltext / DOI:: doi:10.1016/j.ccell.2019.08.010
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/31526756
Print-ISSN:: 1535-6108
TUM Institution:: Institut für Klinische Chemie und Pathobiochemie
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