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Title:

Chondrocyte Culture Parameters for Matrix-Assisted Autologous Chondrocyte Implantation Affect Catabolism and Inflammation in a Rabbit Model

Document type:
Zeitschriftenaufsatz
Author(s):
Sauerschnig M, Berninger MT, Kaltenhauser T, Plecko M, Wexel G, Schoenfelder M , Wienerroither V, Imhoff AB, Schoettle PB, Rosado Balmayor E, Salzmann GM
Abstract:
Cartilage defects represent an increasing pathology among active individuals that affects the ability to contribute to sports and daily life. Cell therapy, such as autologous chondrocyte implantation (ACI), is a widespread option to treat larger cartilage defects still lacking standardization of in vitro cell culture parameters. We hypothesize that mRNA expression of cytokines and proteases before and after ACI is influenced by in vitro parameters: cell-passage, cell-density and membrane-holding...     »
Keywords:
matrix-assisted autologous chondrocyte implantation; cell passage; cell density; membrane-holding time; cytokines; matrix metalloproteinases; animal model
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit
Journal title:
Int. J. Mol. Sci.
Year:
2019
Journal volume:
20
Year / month:
2019-03
Quarter:
1. Quartal
Month:
Mar
Journal issue:
7
Pages contribution:
16
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.3390/ijms20071545
WWW:
https://www.mdpi.com/1422-0067/20/7/1545
Publisher:
MDPI
Publisher address:
Basel
Print-ISSN:
1661-6596
E-ISSN:
1422-0067
Impact Factor:
3.878
Date of publication:
27.03.2019
Semester:
WS 18-19
TUM Institution:
Sportbiologie
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