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Titel:

Ferritin heavy subunit enhances apoptosis of non-small cell lung cancer cells through modulation of miR-125b/p53 axis.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Biamonte, Flavia; Battaglia, Anna Martina; Zolea, Fabiana; Oliveira, Duarte Mendes; Aversa, Ilenia; Santamaria, Gianluca; Giovannone, Emilia Dora; Rocco, Gaetano; Viglietto, Giuseppe; Costanzo, Francesco
Abstract:
Ferritin is a nanocage protein composed by the variable assembly of 24 heavy and light subunits. As major intracellular iron storage protein, ferritin has been studied for many years in the context of iron metabolism. However, recent evidences have highlighted its role, in particular that of the heavy subunit (FHC), in pathways related to cancer development and progression, such as cell proliferation, growth suppressor evasion, cell death inhibition, and angiogenesis. At least partly, the involv...     »
Zeitschriftentitel:
Cell Death Dis
Jahr:
2018
Band / Volume:
9
Heft / Issue:
12
Volltext / DOI:
doi:10.1038/s41419-018-1216-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30518922
TUM Einrichtung:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie)
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