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Title:

Polygenic burden associated to oligodendrocyte precursor cells and radial glia influences the hippocampal volume changes induced by aerobic exercise in schizophrenia patients.

Document type:
Journal Article
Author(s):
Papiol, Sergi; Keeser, Daniel; Hasan, Alkomiet; Schneider-Axmann, Thomas; Raabe, Florian; Degenhardt, Franziska; Rossner, Moritz J; Bickeböller, Heike; Cantuti-Castelvetri, Ludovico; Simons, Mikael; Wobrock, Thomas; Schmitt, Andrea; Malchow, Berend; Falkai, Peter
Abstract:
Hippocampal volume decrease is a structural hallmark of schizophrenia (SCZ), and convergent evidence from postmortem and imaging studies suggests that it may be explained by changes in the cytoarchitecture of the cornu ammonis 4 (CA4) and dentate gyrus (DG) subfields. Increasing evidence indicates that aerobic exercise increases hippocampal volume in CA subfields and improves cognition in SCZ patients. Previous studies showed that the effects of exercise on the hippocampus might be connected to...     »
Journal title abbreviation:
Transl Psychiatry
Year:
2019
Journal volume:
9
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41398-019-0618-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31712617
Print-ISSN:
2158-3188
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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