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Title:

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Fecher, Caroline; Trovò, Laura; Müller, Stephan A; Snaidero, Nicolas; Wettmarshausen, Jennifer; Heink, Sylvia; Ortiz, Oskar; Wagner, Ingrid; Kühn, Ralf; Hartmann, Jana; Karl, Rosa Maria; Konnerth, Arthur; Korn, Thomas; Wurst, Wolfgang; Merkler, Doron; Lichtenthaler, Stefan F; Perocchi, Fabiana; Misgeld, Thomas
Abstract:
Mitochondria vary in morphology and function in different tissues; however, little is known about their molecular diversity among cell types. Here we engineered MitoTag mice, which express a Cre recombinase-dependent green fluorescent protein targeted to the outer mitochondrial membrane, and developed an isolation approach to profile tagged mitochondria from defined cell types. We determined the mitochondrial proteome of the three major cerebellar cell types (Purkinje cells, granule cells and a...     »
Journal title abbreviation:
Nat Neurosci
Year:
2019
Journal volume:
22
Journal issue:
10
Pages contribution:
1731-1742
Fulltext / DOI:
doi:10.1038/s41593-019-0479-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31501572
Print-ISSN:
1097-6256
TUM Institution:
Institut für Neurowissenschaften; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld); Molekulare Immunologie (Prof. Knolle)
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