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Titel:

Digital PCR After MALDI-Mass Spectrometry Imaging to Combine Proteomic Mapping and Identification of Activating Mutations in Pulmonary Adenocarcinoma.

Dokumenttyp:
Journal Article
Autor(en):
Kazdal, Daniel; Longuespée, Rémi; Dietz, Steffen; Casadonte, Rita; Schwamborn, Kristina; Volckmar, Anna-Lena; Kriegsmann, Jörg; Kriegsmann, Katharina; Fresnais, Margaux; Stenzinger, Albrecht; Sültmann, Holger; Warth, Arne; Kriegsmann, Mark
Abstract:
Matrix assisted laser desorption/ionization time-of-flight mass spectrometry imaging (MALDI-MSI) is a powerful tool to analyze the spatial distribution of peptides in tissues. Digital PCR (dPCR) is a method to reliably detect genetic mutations. Biopsy material is often limited due to minimally invasive techniques, but information on diagnosis, prognosis, and prediction is required for subsequent clinical decision making. Thus, saving tissue material during diagnostic workup is highly warranted f...     »
Zeitschriftentitel:
Proteomics Clin Appl
Jahr:
2019
Band / Volume:
13
Heft / Issue:
1
Seitenangaben Beitrag:
e1800034
Sprache:
eng
Volltext / DOI:
doi:10.1002/prca.201800034
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30216696
Print-ISSN:
1862-8346
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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