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Title:

Myelination of Neuronal Cell Bodies when Myelin Supply Exceeds Axonal Demand

Document type:
Article
Author(s):
Almeida, Rafael G.; Pan, Simon; Cole, Katy L. H.; Williamson, Jill M.; Early, Jason J.; Czopka, Tim; Klingseisen, Anna; Chan, Jonah R.; Lyons, David A.
Abstract:
The correct targeting of myelin is essential for nervous system formation and function. Oligodendrocytes in the CNS myelinate some axons, but not others, and do not myelinate structures including cell bodies and dendrites [1]. Recent studies indicate that extrinsic signals, such as neuronal activity [2, 3] and cell adhesion molecules [4], can bias myelination toward some axons and away from cell bodies and dendrites, indicating that, in vivo, neuronal and axonal cues regulate myelin targeting. I...     »
Journal title abbreviation:
Curr Biol
Year:
2018
Journal volume:
28
Journal issue:
8
Pages contribution:
1296-+
Fulltext / DOI:
doi:10.1016/j.cub.2018.02.068
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29628374
Print-ISSN:
0960-9822
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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