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Title:

Defective cholesterol clearance limits remyelination in the aged central nervous system.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Cantuti-Castelvetri, Ludovico; Fitzner, Dirk; Bosch-Queralt, Mar; Weil, Marie-Theres; Su, Minhui; Sen, Paromita; Ruhwedel, Torben; Mitkovski, Miso; Trendelenburg, George; Lütjohann, Dieter; Möbius, Wiebke; Simons, Mikael
Abstract:
Age-associated decline in regeneration capacity limits the restoration of nervous system functionality after injury. In a model for demyelination, we found that old mice fail to resolve the inflammatory response initiated after myelin damage. Aged phagocytes accumulated excessive amounts of myelin debris, which triggered cholesterol crystal formation and phagolysosomal membrane rupture and stimulated inflammasomes. Myelin debris clearance required cholesterol transporters, including apolipoprote...     »
Journal title abbreviation:
Science
Year:
2018
Journal volume:
359
Journal issue:
6376
Pages contribution:
684-688
Fulltext / DOI:
doi:10.1126/science.aan4183
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29301957
Print-ISSN:
0036-8075
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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