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Title:

Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model.

Document type:
Journal Article
Author(s):
Locatelli, Giuseppe; Theodorou, Delphine; Kendirli, Arek; Jordão, Marta Joana Costa; Staszewski, Ori; Phulphagar, Kshiti; Cantuti-Castelvetri, Ludovico; Dagkalis, Athanasios; Bessis, Alain; Simons, Mikael; Meissner, Felix; Prinz, Marco; Kerschensteiner, Martin
Abstract:
Mononuclear phagocytes are key regulators of both tissue damage and repair in neuroinflammatory conditions such as multiple sclerosis. To examine divergent phagocyte phenotypes in the inflamed CNS, we introduce an in vivo imaging approach that allows us to temporally and spatially resolve the evolution of phagocyte polarization in a murine model of multiple sclerosis. We show that the initial proinflammatory polarization of phagocytes is established after spinal cord entry and critically depends...     »
Journal title abbreviation:
Nat Neurosci
Year:
2018
Journal volume:
21
Journal issue:
9
Pages contribution:
1196-1208
Fulltext / DOI:
doi:10.1038/s41593-018-0212-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30127427
Print-ISSN:
1097-6256
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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