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Title:

Non-cell-autonomous function of DR6 in Schwann cell proliferation.

Document type:
Journal Article; Article
Author(s):
Colombo, Alessio; Hsia, Hung-En; Wang, Mengzhe; Kuhn, Peer-Hendrik; Brill, Monika S; Canevazzi, Paolo; Feederle, Regina; Taveggia, Carla; Misgeld, Thomas; Lichtenthaler, Stefan F
Abstract:
Death receptor 6 (DR6) is an orphan member of the TNF receptor superfamily and controls cell death and differentiation in a cell-autonomous manner in different cell types. Here, we report an additional non-cell-autonomous function for DR6 in the peripheral nervous system (PNS). DR6-knockout (DR6 KO) mice showed precocious myelination in the PNS Using an myelination assay, we demonstrate that neuronal DR6 acts in on Schwann cells (SCs) and reduces SC proliferation and myelination independently...     »
Journal title abbreviation:
EMBO J
Year:
2018
Journal volume:
37
Journal issue:
7
Language:
eng
Fulltext / DOI:
doi:10.15252/embj.201797390
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29459438
Print-ISSN:
0261-4189
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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