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Dokumenttyp:
Journal Article; Review
Autor(en):
Ovsepian, Saak V; O'Leary, Valerie B; Ayvazyan, Naira M; Al-Sabi, Ahmed; Ntziachristos, Vasilis; Dolly, James O
Titel:
Neurobiology and therapeutic applications of neurotoxins targeting transmitter release.
Abstract:
Synaptic transmission is a fundamental neurobiological process enabling exchange of signals between neurons as well as neurons and their non-neuronal effectors. The complex molecular machinery of the synaptic vesicle cycle and transmitter release has emerged and developed in the course of the evolutionary race, to ensure adaptive gain and survival of the fittest. In parallel, a generous arsenal of biomolecules and neuroactive peptides have co-evolved, which selectively target the transmitter rel...     »
Zeitschriftentitel:
Pharmacol Ther
Jahr:
2019
Band / Volume:
193
Seitenangaben Beitrag:
135-155
Volltext / DOI:
doi:10.1016/j.pharmthera.2018.08.016
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30149105
Print-ISSN:
0163-7258
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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