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Title:

Digital PCR After MALDI-Mass Spectrometry Imaging to Combine Proteomic Mapping and Identification of Activating Mutations in Pulmonary Adenocarcinoma.

Document type:
Journal Article
Author(s):
Kazdal, Daniel; Longuespée, Rémi; Dietz, Steffen; Casadonte, Rita; Schwamborn, Kristina; Volckmar, Anna-Lena; Kriegsmann, Jörg; Kriegsmann, Katharina; Fresnais, Margaux; Stenzinger, Albrecht; Sültmann, Holger; Warth, Arne; Kriegsmann, Mark
Abstract:
Matrix assisted laser desorption/ionization time-of-flight mass spectrometry imaging (MALDI-MSI) is a powerful tool to analyze the spatial distribution of peptides in tissues. Digital PCR (dPCR) is a method to reliably detect genetic mutations. Biopsy material is often limited due to minimally invasive techniques, but information on diagnosis, prognosis, and prediction is required for subsequent clinical decision making. Thus, saving tissue material during diagnostic workup is highly warranted f...     »
Journal title abbreviation:
Proteomics Clin Appl
Year:
2019
Journal volume:
13
Journal issue:
1
Pages contribution:
e1800034
Language:
eng
Fulltext / DOI:
doi:10.1002/prca.201800034
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30216696
Print-ISSN:
1862-8346
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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