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Title:

Modeling and multiscale characterization of the quantitative imaging based fibrosis index reveals pathophysiological, transcriptome and proteomic correlates of lung fibrosis induced by fractionated irradiation.

Document type:
Journal Article
Author(s):
Zhou, Cheng; Moustafa, Mahmoud R; Cao, Liji; Kriegsmann, Mark; Winter, Martin; Schwager, Christian; Jones, Bleddyn; Wang, Shijun; Bäuerle, Tobias; Zhou, Ping-Kun; Schnölzer, Martina; Weichert, Wilko; Debus, Juergen; Abdollahi, Amir
Abstract:
Pulmonary fibrosis represents a leading cause of morbidity and mortality worldwide. Therapy induced lung fibrosis constitutes a pivotal dose-limiting side effect of radiotherapy and other anticancer agents. We aimed to develop objective criteria for assessment of fibrosis and discover pathophysiological and molecular correlates of lung fibrosis as a function of fractionated whole thoracic irradiation. Dose-response series of fractionated irradiation was utilized to develop a non-invasive and qua...     »
Journal title abbreviation:
Int J Cancer
Year:
2019
Journal volume:
144
Journal issue:
12
Pages contribution:
3160-3173
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.32059
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30536712
Print-ISSN:
0020-7136
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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