Benutzer: Gast  Login
Titel:

Measurement of tumor mutational burden (TMB) in routine molecular diagnostics: in silico and real-life analysis of three larger gene panels.

Dokumenttyp:
Journal Article
Autor(en):
Endris, Volker; Buchhalter, Ivo; Allgäuer, Michael; Rempel, Eugen; Lier, Amelie; Volckmar, Anna-Lena; Kirchner, Martina; von Winterfeld, Moritz; Leichsenring, Jonas; Neumann, Olaf; Penzel, Roland; Weichert, Wilko; Glimm, Hanno; Fröhling, Stefan; Winter, Hauke; Herth, Felix; Thomas, Michael; Schirmacher, Peter; Budczies, Jan; Stenzinger, Albrecht
Abstract:
Assessment of Tumor Mutational Burden (TMB) for response stratification of cancer patients treated with immune checkpoint inhibitors is emerging as a new biomarker. Commonly defined as the total number of exonic somatic mutations, TMB approximates the amount of neoantigens that potentially are recognized by the immune system. While whole exome sequencing (WES) is an unbiased approach to quantify TMB, implementation in diagnostics is hampered by tissue availability as well as time and cost constr...     »
Zeitschriftentitel:
Int J Cancer
Jahr:
2019
Band / Volume:
144
Heft / Issue:
9
Seitenangaben Beitrag:
2303-2312
Sprache:
eng
Volltext / DOI:
doi:10.1002/ijc.32002
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30446996
Print-ISSN:
0020-7136
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
 BibTeX