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Title:

Multimodal analysis of formalin-fixed and paraffin-embedded tissue by MALDI imaging and fluorescence in situ hybridization for combined genetic and metabolic analysis.

Document type:
Journal Article
Author(s):
Huber, Katharina; Kunzke, Thomas; Buck, Achim; Langer, Rupert; Luber, Birgit; Feuchtinger, Annette; Walch, Axel
Abstract:
Multimodal tissue analyses that combine two or more detection technologies provide synergistic value compared to single methods and are employed increasingly in the field of tissue-based diagnostics and research. Here, we report a technical pipeline that describes a combined approach of HER2/CEP17 fluorescence in situ hybridization (FISH) analysis with MALDI imaging on the very same section of formalin-fixed and paraffin-embedded (FFPE) tissue. FFPE biopsies and a tissue microarray of human gast...     »
Journal title abbreviation:
Lab Invest
Year:
2019
Journal volume:
99
Journal issue:
10
Pages contribution:
1535-1546
Fulltext / DOI:
doi:10.1038/s41374-019-0268-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31148595
Print-ISSN:
0023-6837
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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