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Title:

Oncogenic KRAS and the EGFR loop in pancreatic carcinogenesis-A connection to licensing nodes.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Schneeweis, Christian; Wirth, Matthias; Saur, Dieter; Reichert, Maximilian; Schneider, Günter
Abstract:
EGFR signaling has a critical role in oncogenic KRAS-driven tumorigenesis of the pancreas, whereas it is dispensable in other organs. The complex signaling network engaged by oncogenic KRAS and its modulation by EGFR signaling, remains incompletely understood. In order to study early signaling events activated by oncogenic KRAS in the pancreas, we recently developed a novel model system based on murine primary pancreatic epithelial cells enabling the time-specific expression of mutant KrasG12D f...     »
Journal title abbreviation:
Small GTPases
Year:
2018
Journal volume:
9
Journal issue:
6
Pages contribution:
457-464
Language:
eng
Fulltext / DOI:
doi:10.1080/21541248.2016.1262935
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27880072
Print-ISSN:
2154-1248
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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