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Titel:

Hepatitis B virus promotes ?-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion.

Dokumenttyp:
Journal Article
Autor(en):
von Olshausen, Gesa; Quasdorff, Maria; Bester, Romina; Arzberger, Silke; Ko, Chunkyu; van de Klundert, Maarten; Zhang, Ke; Odenthal, Margarete; Ringelhan, Marc; Niessen, Carien M; Protzer, Ulrike
Abstract:
Hepatitis B virus (HBV) infection is a prominent cause of hepatocellular carcinoma (HCC) but the underlying molecular mechanisms are complex and multiple pathways have been proposed such as the activation of the Wnt-/?-catenin-signalling and dysregulation of E-cadherin/?-catenin adherens junctions. This study aimed to identify mechanisms of how HBV infection and replication as well as HBV X protein (HBx) gene expression in the context of an HBV genome influence Wnt-/?-catenin-signalling and form...     »
Zeitschriftentitel:
Oncotarget
Jahr:
2018
Band / Volume:
9
Heft / Issue:
74
Seitenangaben Beitrag:
33947-33960
Sprache:
eng
Volltext / DOI:
doi:10.18632/oncotarget.26103
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30338037
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Virologie
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