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Title:

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels.

Document type:
Journal Article
Author(s):
Ko, Chunkyu; Chakraborty, Anindita; Chou, Wen-Min; Hasreiter, Julia; Wettengel, Jochen M; Stadler, Daniela; Bester, Romina; Asen, Theresa; Zhang, Ke; Wisskirchen, Karin; McKeating, Jane A; Ryu, Wang-Shick; Protzer, Ulrike
Abstract:
Several steps in the HBV life cycle remain obscure because of a lack of robust in vitro infection models. These steps include particle entry, formation and maintenance of covalently closed circular (ccc) DNA, kinetics of gene expression and viral transmission routes. This study aimed to investigate infection kinetics and cccDNA dynamics during long-term culture.We selected a highly permissive HepG2-NTCP-K7 cell clone engineered to express sodium taurocholate co-transporting polypeptide (NTCP) th...     »
Journal title abbreviation:
J Hepatol
Year:
2018
Journal volume:
69
Journal issue:
6
Pages contribution:
1231-1241
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jhep.2018.08.012
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30142426
Print-ISSN:
0168-8278
TUM Institution:
Institut für Virologie
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