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Titel:

Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes.

Dokumenttyp:
Journal Article
Autor(en):
Manske, Katrin; Kallin, Nina; König, Verena; Schneider, Annika; Kurz, Sandra; Bosch, Miriam; Welz, Meike; Cheng, Ru-Lin; Bengsch, Bertram; Steiger, Katja; Protzer, Ulrike; Thimme, Robert; Knolle, Percy A; Wohlleber, Dirk
Abstract:
The liver bears unique immune properties that support both immune tolerance and immunity, but the mechanisms responsible for clearance versus persistence of virus-infected hepatocytes remain unclear. Here, we dissect the factors determining the outcome of antiviral immunity using recombinant adenoviruses that reflect the hepatropism and hepatrophism of hepatitis viruses. We generated replication-deficient adenoviruses with equimolar expression of ovalbumin, luciferase, and green fluorescent prot...     »
Zeitschriftentitel:
Hepatology
Jahr:
2018
Band / Volume:
68
Heft / Issue:
6
Seitenangaben Beitrag:
2089-2105
Sprache:
eng
Volltext / DOI:
doi:10.1002/hep.30080
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29729204
Print-ISSN:
0270-9139
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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