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Title:

Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Inturi, Raviteja; Mun, Kwangchol; Singethan, Katrin; Schreiner, Sabrina; Punga, Tanel
Abstract:
Human adenoviruses (HAdVs) are common human pathogens encoding a highly abundant histone-like core protein, VII, which is involved in nuclear delivery and protection of viral DNA as well as in sequestering immune danger signals in infected cells. The molecular details of how protein VII acts as a multifunctional protein have remained to a large extent enigmatic. Here we report the identification of several cellular proteins interacting with the precursor pVII protein. We show that the cellular E...     »
Journal title abbreviation:
J Virol
Year:
2018
Journal volume:
92
Journal issue:
3
Fulltext / DOI:
doi:10.1128/JVI.01154-17
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29142133
Print-ISSN:
0022-538X
TUM Institution:
Institut für Virologie
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