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Title:

Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes.

Document type:
Journal Article
Author(s):
Manske, Katrin; Kallin, Nina; König, Verena; Schneider, Annika; Kurz, Sandra; Bosch, Miriam; Welz, Meike; Cheng, Ru-Lin; Bengsch, Bertram; Steiger, Katja; Protzer, Ulrike; Thimme, Robert; Knolle, Percy A; Wohlleber, Dirk
Abstract:
The liver bears unique immune properties that support both immune tolerance and immunity, but the mechanisms responsible for clearance versus persistence of virus-infected hepatocytes remain unclear. Here, we dissect the factors determining the outcome of antiviral immunity using recombinant adenoviruses that reflect the hepatropism and hepatrophism of hepatitis viruses. We generated replication-deficient adenoviruses with equimolar expression of ovalbumin, luciferase, and green fluorescent prot...     »
Journal title abbreviation:
Hepatology
Year:
2018
Journal volume:
68
Journal issue:
6
Pages contribution:
2089-2105
Language:
eng
Fulltext / DOI:
doi:10.1002/hep.30080
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29729204
Print-ISSN:
0270-9139
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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