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Titel:

An orthogonal proteomic survey uncovers novel Zika virus host factors.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Scaturro, Pietro; Stukalov, Alexey; Haas, Darya A; Cortese, Mirko; Draganova, Kalina; P?aszczyca, Anna; Bartenschlager, Ralf; Götz, Magdalena; Pichlmair, Andreas
Abstract:
Zika virus (ZIKV) has recently emerged as a global health concern owing to its widespread diffusion and its association with severe neurological symptoms and microcephaly in newborns. However, the molecular mechanisms that are responsible for the pathogenicity of ZIKV remain largely unknown. Here we use human neural progenitor cells and the neuronal cell line SK-N-BE2 in an integrated proteomics approach to characterize the cellular responses to viral infection at the proteome and phosphoproteom...     »
Zeitschriftentitel:
Nature
Jahr:
2018
Band / Volume:
561
Heft / Issue:
7722
Seitenangaben Beitrag:
253-257
Volltext / DOI:
doi:10.1038/s41586-018-0484-5
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30177828
Print-ISSN:
0028-0836
TUM Einrichtung:
Institut für Virologie
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