Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity.

Norris, Jill M; Lee, Hye-Seung; Frederiksen, Brittni; Erlund, Iris; Uusitalo, Ulla; Yang, Jimin; Lernmark, Åke; Simell, Olli; Toppari, Jorma; Rewers, Marian; Ziegler, Anette-G; She, Jin-Xiong; Onengut-Gumuscu, Suna; Chen, Wei-Min; Rich, Stephen S; Sundvall, Jouko; Akolkar, Beena; Krischer, Jeffrey; Virtanen, Suvi M; Hagopian, William; TEDDY Study Group; Rewers, Marian; Bautista, Kimberly; Baxter, Judith; Bedoy, Ruth; Felipe-Morales, Daniel; Driscoll, Kimberly; Frohnert, Brigitte I; Gesualdo, Patricia; Hoffman, Michelle; Karban, Rachel; Liu, Edwin; Norris, Jill; Samper-Imaz, Adela; Steck, Andrea; Waugh, Kathleen; Wright, Hali; Toppari, Jorma; Simell, Olli G; Adamsson, Annika; Ahonen, Suvi; Hyöty, Heikki; Ilonen, Jorma; Jokipuu, Sanna; Kallio, Tiina; Karlsson, Leena; Kähönen, Miia; Knip, Mikael; Kovanen, Lea; Koreasalo, Mirva; Kurppa, Kalle; Latva-Aho, Tiina; Lönnrot, Maria; Mäntymäki, Elina; Multasuo, Katja; Mykkänen, Juha; Niininen, Tiina; Niinistö, Sari; Nyblom, Mia; Rajala, Petra; Rautanen, Jenna; Riikonen, Anne; Riikonen, Mika; Rouhiainen, Jenni; Romo, Minna; Simell, Tuula; Simell, Ville; Sjöberg, Maija; Stenius, Aino; Leppänen, Maria; Vainionpää, Sini; Varjonen, Eeva; Veijola, Riitta; Virtanen, Suvi M; Vähä-Mäkilä, Mari; Åkerlund, Mari; Lindfors, Katri; She, Jin-Xiong; Schatz, Desmond; Hopkins, Diane; Steed, Leigh; Thomas, Jamie; Adams, Janey; Silvis, Katherine; Haller, Michael; Gardiner, Melissa; McIndoe, Richard; Sharma, Ashok; Williams, Joshua; Young, Gabriela; Anderson, Stephen W; Jacobsen, Laura; Ziegler, Anette G; Beyerlein, Andreas; Bonifacio, Ezio; Hummel, Michael; Hummel, Sandra; Foterek, Kristina; Janz, Nicole; Kersting, Mathilde; Knopff, Annette; Koletzko, Sibylle; Peplow, Claudia; Roth, Roswith; Scholz, Marlon; Stock, Joanna; Warncke, Katharina; Wendel, Lorena; Winkler, Christiane; Lernmark, Åke; Agardh, Daniel; Aronsson, Carin Andrén; Ask, Maria; Bremer, Jenny; Carlsson, Ulla-Marie; Cilio, Corrado; Ericson-Hallström, Emelie; Fransson, Lina; Gard, Thomas; Gerardsson, Joanna; Bennet, Rasmus; Hansen, Monica; Hansson, Gertie; Hyberg, Susanne; Johansen, Fredrik; Jonsdottir, Berglind; Larsson, Helena Elding; Lindström, Marielle; Lundgren, Markus; Månsson-Martinez, Maria; Markan, Maria; Melin, Jessica; Mestan, Zeliha; Ottosson, Karin; Rahmati, Kobra; Ramelius, Anita; Salami, Falastin; Sibthorpe, Sara; Sjöberg, Birgitta; Swartling, Ulrica; Amboh, Evelyn Tekum; Törn, Carina; Wallin, Anne; Wimar, Åsa; Åberg, Sofie; Hagopian, William A; Killian, Michael; Crouch, Claire Cowen; Skidmore, Jennifer; Carson, Josephine; Dalzell, Maria; Dunson, Kayleen; Hervey, Rachel; Johnson, Corbin; Lyons, Rachel; Meyer, Arlene; Mulenga, Denise; Tarr, Alexander; Uland, Morgan; Willis, John; Becker, Dorothy; Franciscus, Margaret; Dalmagro-Elias Smith, MaryEllen; Daftary, Ashi; Klein, Mary Beth; Yates, Chrystal; Krischer, Jeffrey P; Abbondondolo, Michael; Austin-Gonzalez, Sarah; Avendano, Maryouri; Baethke, Sandra; Brown, Rasheedah; Burkhardt, Brant; Butterworth, Martha; Clasen, Joanna; Cuthbertson, David; Eberhard, Christopher; Fiske, Steven; Garcia, Dena; Garmeson, Jennifer; Gowda, Veena; Heyman, Kathleen; Laras, Francisco Perez; Lee, Hye-Seung; Liu, Shu; Liu, Xiang; Lynch, Kristian; Malloy, Jamie; McCarthy, Cristina; Meulemans, Steven; Parikh, Hemang; Shaffer, Chris; Smith, Laura; Smith, Susan; Sulman, Noah; Tamura, Roy; Uusitalo, Ulla; Vehik, Kendra; Vijayakandipan, Ponni; Wood, Keith; Yang, Jimin; Akolkar, Beena; Bourcier, Kasia; Briese, Thomas; Johnson, Suzanne Bennett; Triplett, Eric; Yu, Liping; Miao, Dongmei; Bingley, Polly; Williams, Alistair; Chandler, Kyla; Rokni, Saba; Williams, Claire; Wyatt, Rebecca; George, Gifty; Grace, Sian; Erlund, Iris; Salminen, Irma; Sundvall, Jouko; Leiviskä, Jaana; Kangas, Nina; Arohonka, Petra; Erlich, Henry; Mack, Steven J; Fear, Anna Lisa; Ke, Sandra; Mulholland, Niveen; Rich, Stephen S; Chen, Wei-Min; Onengut-Gumuscu, Suna; Farber, Emily; Pickin, Rebecca Roche; Davis, Jordan; Gallo, Dan; Bonnie, Jessica; Campolieto, Paul     «

Norris, Jill M; Lee, Hye-Seung; Frederiksen, Brittni; Erlund, Iris; Uusitalo, Ulla; Yang, Jimin; Lernmark, Åke; Simell, Olli; Toppari, Jorma; Rewers, Marian; Ziegler, Anette-G; She, Jin-Xiong; Onengut-Gumuscu, Suna; Chen, Wei-Min; Rich, Stephen S; Sundvall, Jouko; Akolkar, Beena; Krischer, Jeffrey; Virtanen, Suvi M; Hagopian, William; TEDDY Study Group; Rewers, Marian; Bautista, Kimberly; Baxter, Judith; Bedoy, Ruth; Felipe-Morales, Daniel; Driscoll, Kimberly; Frohnert, Brigitte I; Gesualdo, Pat...     »

We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested case-control study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentration was measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in , and were analyzed as effect modifiers of 25(OH)D. Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with lower IA risk (odds ratio = 0.93 for a 5 nmol/L difference; 95% CI 0.89, 0.97). Moreover, this association was modified by rs7975232 (interaction = 0.0072), where increased childhood 25(OH)D was associated with a decreasing IA risk based upon number of minor alleles: 0 (1.00; 0.93, 1.07), 1 (0.92; 0.89, 0.96), and 2 (0.86; 0.80, 0.92). Vitamin D and may have a combined role in IA development in children at increased genetic risk for type 1 diabetes.     «

We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested case-control study of 376 IA case subjects and up to...     »